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About the laboratory

The Central Research Laboratory has been operating since October 1989. It is TNMU’s experimental base for training academic and research staff: CRL staff give practical and methodological support to University researchers working on doctoral and candidate dissertations.

Main areas of activity

• Biochemical and enzyme immunoassay studies: comprehensive analysis of biological fluids, determination of metabolic markers, tumor markers, cytokines and hormones.
• Experimental work: modeling of pathological conditions in vivo in compliance with ethical standards.
• Organometric and massometric measurements: studies of organs and tissues of laboratory animals.
• Statistical analysis: processing of research data sets.

Infrastructure and standards (GLP)

The laboratory layout was designed in strict compliance with the principles of Good Laboratory Practice (GLP):

• Area and premises: 13 working rooms (total area 228.93 m²), laid out so as to separate activities properly and avoid cross-contamination.
• Animal housing: a separate isolated room for housing and acclimatizing test systems (laboratory animals).
• Reagent storage: isolated rooms for the safe storage of hazardous consumables and chemical reagents.

About the laboratory

The Microbiology and Parasitology Laboratory was established in March 2003 by order of the Ministry of Health of Ukraine and an order of the Rector of the Ternopil Medical Academy.

Organizational structure and staff

The laboratory comprises two main units:

• Bacteriological laboratory
• Parasitological laboratory

Staff: head of the laboratory, 3 bacteriologists, a senior laboratory technician and 3 laboratory technicians.

Research interests and areas of study

• Bacteriological and parasitological examination of biological material from humans and experimental animals.
• Human microbial ecology across age groups in health and disease; study of human and environmental microbiocenoses.
• Study of reference and clinical bacterial strains and the effects of various factors on them.
• Adhesive, antagonistic and anticomplementary properties of microorganisms and antibiotic susceptibility of bacteria.
• Composition of the oropharyngeal microbial biotope in children with frequent and prolonged illness.
• The influence of microorganisms on the development of somatic diseases.
• Dental plaque microflora in health and in the presence of orthodontic appliances for dental arch correction.
• Issues in the use of probiotics in medicine.
• Diagnosis and study of giardiasis and helminthiases.

Premises and permits

• Total area: 151.7 m²
• Working area: 108.5 m²
• Number of working rooms: 7
• Special permits: the laboratory holds an official permit to work with pathogens of hazard groups III–IV (Permit No. 04-03/355).

About the laboratories

These ILC laboratories carry out research at the molecular genetic and cellular levels. They have equipment for work with nucleic acids and cell lines, and for biochemical and enzyme immunoassay analyses.

Main areas of activity

• Molecular genetic studies: detection and quantification of DNA/RNA of infectious agents by the polymerase chain reaction (PCR); analysis of genetic polymorphisms.
• Cell cultures: in vitro culture of stem cells, cytotoxicity assessment, regenerative medicine studies and biocompatibility of nanomaterials.
• Virology: study of vector-borne infections transmitted by ticks and mosquitoes (Lyme borreliosis and others).
• Biochemistry and ELISA: an extended range of enzyme immunoassays.

Infrastructure

• Total area: 215.8 m²
• Number of working rooms: 12

About the laboratory

The Interdepartmental Teaching and Research Laboratory (ITRL) was established to carry out general clinical testing and to support the research and practical work of TNMU students and researchers.

Main areas of activity

• Hematological studies: full blood count, study of blood cell morphology.
• General clinical studies: analysis of biological fluids (urine, exudates, transudates and others).
• Biochemical studies: determination of protein, carbohydrate and lipid metabolism parameters.
• Teaching: support of practical classes and master classes for students of the medical and pharmaceutical faculties.

Infrastructure

• Total area: 50.2 m²
• Number of working rooms: 4
• Staff: highest-category laboratory physicians with many years of clinical experience.

About the laboratory

The Morphological Research Sector studies the micro- and ultrastructure of organs and tissues. The laboratory is equipped with electron and light microscopes.

Main areas of activity

• Electron microscopy: ultrastructural analysis of cells, tissues and nanoparticles (TEM).
• Histological studies: preparation of microscope slides, staining by standard and special protocols, morphometric analysis.
• Immunohistochemistry: highly specific labeling of proteins and antigens in tissues using monoclonal and polyclonal antibodies.
• Digital pathology: slide scanning and digital image analysis (for example, QuPath).

Infrastructure

• Total area: 157.75 m²
• Number of working rooms: 8

About the laboratory

The laboratory assesses human psychophysiological status, the neurodynamic properties of higher nervous activity and autonomic regulation.

Main areas of activity

• Neurodynamics: measurement of visual and auditory motor reaction times and of the functional mobility of nervous processes.
• Cognitive function: testing of attention, memory, thinking and mental performance.
• Stress resilience: assessment of psycho-emotional strain and study of the body’s adaptive reserves.
• Instrument systems: use of modern computerized diagnostic systems.

Infrastructure

• Total area: 158.6 m²
• Number of working rooms: 5

About the laboratory

The Drug Quality Control Research Laboratory carries out fundamental and applied research in pharmaceutical analysis, standardization and quality control of medicinal products.

Besides quality control, the laboratory runs research projects and trains research personnel.

Organizational structure

The laboratory comprises two main units:

• Sector of chemical, physical and physicochemical methods of analysis.
• Sector of pharmaco-technological testing.

Main areas of activity and methods

• Chromatographic and spectral analysis: high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC) and spectrophotometry.
• Classical chemical analysis: automated titrimetric methods and Karl Fischer titration.
• Pharmaceutical analysis: identification and quantification of active substances, determination of impurities and degradation products, stability studies and comprehensive quality assessment of medicinal products.
• Pharmaco-technological testing: testing of pharmaco-technological parameters of various dosage forms in accordance with the requirements of the State Pharmacopoeia of Ukraine and regulatory documentation.

Research projects, academic activity and implementation

• International grants: the laboratory currently hosts an international NATO grant project focused on research in modern pharmaceutical and analytical control.
• Training of research personnel: 4 PhD dissertations and 1 doctoral dissertation are being carried out at the laboratory.
• Implementation of results: the results have been implemented in the practice of JSC “Farmak” and the State Service of Ukraine on Medicines and Drugs Control.